Katherine Mayhew Flegal is an American epidemiologist and senior scientist at the Centers for Disease Control and Prevention's National Center for Health Statistics. She is one of the most highly cited scientists in the field of the epidemiology of obesity according to Thomson Reuters Katherine Flegal Interview and has been called "one of the great epidemiologists" by former FDA Commissioner David A. Kessler.
Next Flegal completed Master's and Ph.D. degrees at Cornell University, expanding her interests in statistics and epidemiology and receiving her Ph.D. in 1982. When a post-doctoral position at the University of Pittsburgh offered little opportunity for research, Flegal completed a second master's degree there, in public health (MPH). In 1987, after working at the University of Michigan's biostatistics department, Flegal began working at the Centers for Disease Control (CDC).
In 2005, Flegal and co-authors from CDC and NIH published a study in JAMA which found that being overweight was associated with lower mortality than normal weight and that obesity was associated with slightly higher mortality. The study received considerable opposition, in part because its conclusions differed from those of another paper published by senior CDC authors in March 2004. After considerable discussion,Kolata, Gina. Rethinking Thin, The New Science of Weight Loss – and the Myths and Realities of Dieting (2007), 201-208.Lassek, William D. and Steven J.C. Gaulin. Why Women Need Fat (2012), 96-101 the CDC accepted Flegal's figures as correct. Flegal herself has stated "Our paper was straightforward and defensible, used only publicly available data, and corrected the errors in several previous papers on the topic". Flegal's article received CDC's highest science award, the Charles C. Shepard award, in 2006.
In 2013, Flegal was the lead author of a systematic review and meta-analysis published in JAMA regarding the association of overweight and obesity with mortality. In a large sample, drawn from other countries as well as the U.S., overweight people had lower mortality relative to people of normal weight. The work examined the results of 97 studies that had included 2.88 million people.
Jeffrey Scott Flier, the dean of Harvard Medical School, convened a panel of experts to discuss the paper at Harvard on February 20, 2013. The panel's members suggested that Flegal's meta-analysis paper contained methodological errors, and criticized the selection criteria used for washing out too many people. Harvard's own subsequent analysis supported its position, but also received criticisms over how the researchers determined who to include.
Many researchers accept the results of Flegal's 2005 and 2013 papers and see them as an illustration of what is known as the "obesity paradox". In 2021, Diana Thomas described Flegal's 2013 meta-analysis as "the gold standard" of obesity research.
In 2021, Flegal published a paper about her experiences with her 2005 and 2013 papers, concluding "Scientific findings should be evaluated on their merits, not on the basis of whether they fit a desired narrative."
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